compound introduction
FEN1抑制选择性地损害Cdc4和Mre11a缺失的结肠癌细胞的增殖，这两种细胞在结直肠癌中经常发生突变。由于FEN1在LP-BER中的作用，它也成为一个潜在的化学增敏靶点，因为它对甲基磺酸诱导的烷基化损伤的修复至关重要，并且它的敲低或抑制增加了胶质母细胞瘤和结直肠癌细胞系对替莫唑胺的敏感性。 FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines.
