A-803467能够抑制感觉神经元的自发和诱发动作电位。它具有镇痛作用。A-803467能够在体内减少脊髓背角神经元的放电。 小分子A-803467是一种有效的选择性Nav1.8钠离子通道阻滞剂。Nav1.8是一种抗河豚毒素（TTX-R）钠离子通道，通过在周围感觉神经元中传递疼痛刺激而产生痛觉；A-803467通过阻滞该通道，能够对多种模型产生不同程度的疼痛减轻作用。A-803467已被用于进一步探究Nav1.8在传递疼痛刺激中的作用. A-803467 inhibits spontaneous and evoked action potentials in sensory neurons. It exhibits antinociceptive effects.A-803467 decreases the firing in spinal dorsal horn neurons in vivo. The small molecule A-803467 is a potent and selective Nav1.8 sodium channel blocker. Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel that contributes to pain sensation by transmitting pain stimuli in peripheral sensory neurons; blockage of this channel by A-803467 reduces pain with varying effectiveness in a number of different models.A-803467 has been used to further understand the role of Nav1.8 in transmitting pain stimuli and also can be used as an analgesic
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A-803467
Dangerous GoodsCAS number：944261-79-4 molecular formula：C19H16ClNO4
overview
compound introduction
Specs
| Chinese alias | 5-(4-氯苯基)-N-(3,5-二甲氧基苯基)呋喃-2-甲酰胺 | ||
| English alias | MFCD10574689 | 5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furamide | AS-55982 | N-t-butoxycarbonyl-S-tritylcysteine | 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)- 2-furancarboxamide. | BCP9000209 | HMS3656L08 | EX-A083 | AB07953 | EC-000.2378 | SMR004702 | ||
| CAS number | 944261-79-4 | molecular formula | C19H16ClNO4 |
| molecular weight | 357.79 g/mol | Exact mass | - |
| PSA | 60.700 Ų | logp | 4.4 |
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H302: 吞食有害
Statement of Preventive Measures：
P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P317: 如果被吞咽：请寻求医疗帮助。
WGK Germany：
3
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