Cirsiliol is a potent and selective 5-lipoxygenase inhibitor and a competitive low affinity benzodiazepine receptor ligand. In Vitro In concentrations from 0.01 to 300 μM, cirsiliol causes concentration-dependent relaxation of rat isolated ileum. Cirsiliol may inhibit Ca 2+ influx but stimulates Ca 2+ release from intracellular stores. Treatment with rhamnetin or cirsiliol reduces the proliferation of NSCLC cells through the suppression of radiation-induced Notch-1 expression. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo In xenograft mouse model, tumor volume is significantly reduced by combinational treatment with irradiation and rhamnetin or cirsiliol compared with irradiation alone. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Assay NSCLC, NCI-H1299, NCI-H460, WI-26 VA4 and MRC-5 cell lines are exposed to a single dose of γ-rays. Cells are then treated with rhamnetin and cirsiliol (5, 10, 15, 20, 25 μM) dissolved in DMSO for 4 h. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:5-Lipoxygenase
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Cirsiliol
Dangerous GoodsCAS number：34334-69-5 molecular formula：C17H14O7
overview
compound introduction
Specs
| Chinese alias | 蓟马醇 | ||
| English alias | 3',4',5-Trihydroxy-6,7-dimethoxyflavone | 3',4',5-trihydroxy-6,7-dimethoxy-flavone | PbS Quantum Dots-1600 nm | 5,3'',4''-Trihydroxy-6,7-dimethoxyflavone | 5,3',4'-trihydroxy-6,7-dimethoxyflavone | LMPK12111227 | E80755 | 2-(3,4-Dihydroxy-phenyl)-5-hydrox | ||
| CAS number | 34334-69-5 | molecular formula | C17H14O7 |
| molecular weight | 330.29 g/mol | Exact mass | ≥99% |
| PSA | 105.000 Ų | logp | 2.6 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H302: 吞食有害
Statement of Preventive Measures：
P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P317: 如果被吞咽：请寻求医疗帮助。
WGK Germany：
3
RTECS：
DJ3011100
Production methods and uses
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downstream information
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MSDS
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