16F16, a protein disulfide bond isomerase (PDI) inhibitor, was first identified in a screen for compounds that screen Huntington protein-induced apoptosis. 16F16 not only inhibited apoptosis induced by the misfolded protein mutant Huntington gene, but also protected rat neurons from Aβ peptide-induced cell death. This inhibitor action helps to identify a novel mechanism in which the cell death pathway is regulated by protein misfolding through PDI upregulation. 16F16, a protein disulfide bond isomerase (PDI) inhibitor, was first identified in a screen for compounds that screen Huntington protein-induced apoptosis. 16F16 not only inhibited apoptosis induced by the misfolded protein mutant Huntington gene, but also protected rat neurons from Aβ peptide-induced cell death. This inhibitor action helps to identify a novel mechanism in which the cell death pathway is regulated by protein misfolding through PDI upregulation.
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PDI inhibitor 16F16
Dangerous GoodsCAS number：922507-80-0 molecular formula：C16H17ClN2O3
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 922507-80-0 | molecular formula | C16H17ClN2O3 |
| molecular weight | 320.77 g/mol | Exact mass | ≥98%(HPLC) |
| PSA | 62.400 Ų | logp | 2.3 |
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