CAS number：253863-19-3 molecular formula：C19H22O7
（5Z）-7-氧杂烯醇是一种天然抗原生动物抑制剂，不可逆的选择性抑制 TAK1和 VEGF-R2，IC50值分别为 8 nM 和 52 nM。 应用 （5Z）-7-氧杂烯醇用于：1.用作转化生长因子β激活激酶1(TAK1) 抑制剂，作用于人类结肠癌细胞；2.用作TAK1特异性抑制剂对小鼠腹腔注射，能造成主动脉缩窄；3.用作TAK1抑制剂处理细胞，用于荧光酶素报告基因检测；4.测试生长分化因子（GDF2）介导的失巢凋亡。 5Z-7-Oxozeaenol is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK1 and low activity against MEK1 with IC50 of 411 nM, it is also an inhibitor of VEGF-R2 with IC50 of 52 nM.
| Chinese alias | (3S,5Z,8S,9S,11E)-3,4,9,10-四氢-8,9,16-三羟基-14-甲氧基-3-甲基-1H-2-苯并氧杂环十四烷-1,7(8H) -二酮 | ||
| English alias | 5Z-7-Oxozeaenol | AKOS030213203 | 5Z-7-Oxozeaenol, >=98% (HPLC) | NCGC00186421-07 | N-iodosuccinic acid imide | BDBM50042034 | LL-Z1640-2 | SCHEMBL3841555 | FR148083 | FR-148083 | CHEBI:67559 | Q27074007 | L783279 | (2E,5S,6S,8Z,11S)-5,6,15-trihydroxy-17- | ||
| CAS number | 253863-19-3 | molecular formula | C19H22O7 |
| molecular weight | 362.37 g/mol | Exact mass | - |
| PSA | 113.000 Ų | logp | 2.600 |
No numbering system information yet
No physical and chemical property information yet
No production method and use information yet
No upstream information yet
No downstream information yet
