Resolvin D2

Resolvins是衍生自二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）的有效脂质介体家族。除了具有抗炎作用外，Resolvins还可以促进炎症反应恢复为非发炎状态。Resolvin D2是由15-和5-脂氧合酶对DHA的顺序氧合后产生的，其生理作用是抑制中性粒细胞向炎症部位的过度转运。在每只小鼠低至10 pg的剂量下，它可将酵母聚糖刺激的PMN浸润降低70％，并在1 nM时显着降低PAF刺激的白细胞粘附和迁移。此外，通过刺激一氧化氮的产生，RESOLVIN D2剂量依赖性地降低了白细胞与内皮的相互作用 Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state. Resolvin D2 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase and functions to dampen excessive neutrophil trafficking to sites of inflammation. It reduces zymosan-stimulated PMN infiltration by 70% at doses as low as 10 pg per mouse and significantly reduces PAF-stimulated leukocyte adherence and emigration at 1 nM. Also, by stimulating nitric oxide production, resolvin D2 dose dependently decreases leukocyte-endothelial interactions. In a murine model of sepsis, resolvin D2 reduces leukocyte and PMN infiltration, decreases production of pro-inflammatory cytokines, and promotes phagocyte-mediated bacterial clearance.

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