CAS number：2304549-73-1 molecular formula：C16H14ClF3N4O2
Information GFB-8438 GFB-8438 is a novel, potent, and subtype selective TRP channel subfamily C (TRPC) inhibitor that is equipotent against TRPC4 and TRPC5 with IC50 of 0.18 μM and 0.29 μM, and shows excellent selectivity against TRPC6, other TRP family members , NaV 1.5, as well as limited activity against the hERG channel . Targets hERG channel ; TRPC4 (Cell-free assay); TRPC5 (Cell-free assay) ; 0.18 μM; 0.29 μM
| Chinese alias | - | ||
| English alias | 3(2H)-Pyridazinone,4-chloro-5-[3-oxo-4-[[2-(trifluoromethyl)phenyl]methyl]-1-piperazinyl]- | ||
| CAS number | 2304549-73-1 | molecular formula | C16H14ClF3N4O2 |
| molecular weight | 386.76 g/mol | Exact mass | - |
| PSA | 65.000 Ų | logp | 1.445 |
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