Information DTP3 DTP3 is a selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor and is able to restore MKK7/JNK activation. DTP3 inhibits cancer-selective NF-κB survival pathway. Targets GADD45β/MKK7 ; NF-κB In vitro DTP3 physically interacts with MKK7, both in isolation and within the complex with GADD45β, and dissociates the GADD45β/MKK7 complex via an allosteric mechanism. DTP3 selectively kills cells and induces apoptosis in MM cells with functional MKK7 and elevated GADD45β expression without toxicity to normal cells. In addition, DTP3 displays synergistic activity with bortezomib in two different MM cell lines, exhibiting a combination index of 0.21 in U266 cells and of 0.56 in KMS-12 cells. In vivo DTP3 (14.5 mg/kg/day) exhibits potent antitumor activity against MM in mouse plasmacytoma model. Cell Research(from reference) Cell lines：CD138+ cells Concentrations：~300 nM Incubation Time：8 days
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DTP3
Dangerous GoodsCAS number：1809784-29-9 molecular formula：C26H35N7O5
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compound introduction
Specs
| Chinese alias | - | ||
| English alias | (2R)-2-[[(2R)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-N-[(2R)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)pentanamide | HY-100538 | AC-36751 | D-Phenylalaninamide, N-acetyl-D-tyrosyl-D-arginyl- | MS-29734 | E73458 | NSC785669 | N | ||
| CAS number | 1809784-29-9 | molecular formula | C26H35N7O5 |
| molecular weight | 525.6 g/mol | Exact mass | ≥99% |
| PSA | 215.000 Ų | logp | -0.900 |
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
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