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IU1

Dangerous Goods

CAS number：314245-33-5    molecular formula：C18H21FN2O

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physicochemical properties
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overview

compound introduction

IU1 是一种特异性的 Usp14 抑制剂，IC50 为 4-5 μM。 应用： IU1已用于抑制人神经母细胞瘤细胞（SH-SY5Y）中的泛素特异性肽酶14（USP14）并用于泛素-若丹明水解板测定。IU1是一种细胞渗透性的，可逆的proteasome（蛋白酶体）选择性抑制剂，作用于USP14时，IC50为4.7 μ M，作用于IsoT时 选择性高25倍。IU1可诱导自噬。 IU1 is a special Usp14 inhibitor with an IC50 of 4-5 μM.

Specs

Chinese alias-
English aliasBDBM50437694 | HMS2742M13 | Usp14 inhibitor | AMY24153 | NCGC00249377-08 | HMS3743A07 | EN300-72884 | MFCD01917473 | SR-01000010584 | 1-(1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(pyrrolidin-1-yl)ethanone | SCHEMBL6923146 | EX-A2079 | MLS001032847
CAS number314245-33-5molecular formulaC18H21FN2O
molecular weight300.37 g/molExact mass-
PSA25.200 Ųlogp3.500

numbering system

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physicochemical properties

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Safety information

pictogram：
GHS05
Signal word：
Danger
Hazard Statement：
H318: 造成严重的眼睛损伤
Statement of Preventive Measures：
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P305+P354+P338: 如果进入眼睛：立即用水冲洗几分钟。取下隐形眼镜（如果有的话），并且操作简单。继续冲洗。 P317: 寻求紧急医疗救助。
WGK Germany：
3

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