Ixazomib Citrate (MLN9708)

Dangerous Goods

CAS number：1239908-20-3 molecular formula：C20H23BCl2N2O9

overview

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physicochemical properties

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MSDS

overview

compound introduction

产品应用： Ixazomib citrate (MLN9708, Ninlaro) 是 Ixazomib (MLN2238)的前体，Ixazomib (MLN2238) 是一种选择性的 20S proteasome 的口服生物利用抑制剂，可抑制胰凝乳蛋白酶样蛋白水解(β5)位点，其IC50值和Ki值分别为3.4 nM和为0.93 nM。Ixazomib (MLN2238) 还抑制caspase样(β1)和胰蛋白酶样(β2)的蛋白水解位点，IC50分别为31 nM和3500 nM。 Information Ixazomib citrate (MLN9708, Ninlaro) is a prodrug of Ixazomib (MLN2238), which is a selective, orally bioavailable inhibitor of20S proteasomethat inhibits the chymotrypsin-like proteolytic (β5) site with IC50 of 3.4 nM and Ki of 0.93 nM, respectively. Ixazomib (MLN2238) also inhibits caspase-like (β1) and trypsin-like (β2) proteolytic sites with IC50 of 31 nM and 3500 nM, respectively. Targets 20S proteasome β5 site (Cell-free assay); 20S proteasome β5 site (Cell-free assay); 20S proteasome β1 site (Cell-free assay); 20S proteasome β2 site (Cell-free assay) 0.93 nM(Ki); 3.4 nM; 31 nM; 3500 nM

Specs

Chinese alias	-
English alias	AKOS030632768 \| BCP16600 \| IXAZOMIB CITRATE [MI] \| IXAZOMIB CITRATE [ORANGE BOOK] \| DTXSID60924652 \| NCGC00522453-02 \| AC-35344 \| EX-A3660 \| Ixazomib citrate [USAN] \| 1,3,2-Dioxaborolane-4,4-diacetic acid, 2-((1R)-1-((2-((2,5-dichlorobenzoyl)amino)acetyl)
CAS number	1239908-20-3	molecular formula	C20H23BCl2N2O9
molecular weight	517.12 g/mol	Exact mass	10mM in DMSO
PSA	168.000 Å²	logp	3.497

numbering system

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physicochemical properties

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Safety information

pictogram：

GHS08

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Danger

Hazard Statement：

H360: 可能损害生育力或未出生的孩子 H362: 可能对母乳喂养的孩子造成伤害

Statement of Preventive Measures：

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P263: 避免在怀孕期间/哺乳期间接触。 P203: 使用前，获取、阅读并遵守所有安全说明。 P318: 如果暴露或担心，请就医。