VLX600

Dangerous Goods

CAS number：327031-55-0 molecular formula：C17H15N7

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physicochemical properties

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MSDS

overview

compound introduction

Information VLX600 VLX600 is a novel iron-chelating inhibitor of oxidative phosphorylation (OXPHOS) , potentiates the effect of radiation in tumor spheroids in a synergistic manner. VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation. VLX600 induces autophagy and mitochondrial inhibition with antitumor activity. Targets OXPHOS In vitro VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation. Mitochondrial inhibition with VLX600 has a direct antitumor effect in vitro while appearing to promote glycolysis through increased AKT signaling and glucose transporter expression. When combined with imatinib, VLX600 prevents imatinib-induced cell cycle escape and reduces p27 expression, leading to increased apoptosis when compared to imatinib alone. In vivo VLX600 induces the formation of autolysosomes in vivo. VLX600 displays tumour growth inhibition in vivo. When combined with imatinib, VLX600 reduces p27 expression and prevents imatinib-induced cell cycle escape, likely potentiating the antitumoral effects of Kit inhibition. Cell Research(from reference) Cell lines：human GIST-T1 cell line, human HG129 cell line, human GIST-882 cell line, Concentrations：2 μM, 6 μM, 12 μM Incubation Time：48–72h

Specs

Chinese alias	-
English alias	AKOS000354357 \| EN300-395210 \| MFCD01305422 \| Z2694498001 \| AS-79800 \| 6-methyl-3-{(2E)-2-[1-(pyridin-2-yl)ethylidene]hydrazinyl}-5H-[1,2,4]triazino[5,6-b]indole \| SCHEMBL20518451 \| Ethanone, 1-(2-pyridinyl)-, 2-(6-methyl-5H-1,2,4-triazino(5,6-b)indol-3-y
CAS number	327031-55-0	molecular formula	C17H15N7
molecular weight	317.35 g/mol	Exact mass	10mM in DMSO
PSA	91.700 Å²	logp	3.589

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Safety information

pictogram：

GHS07

Signal word：

Warning

Hazard Statement：

H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激

Statement of Preventive Measures：

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P312: 打电话给毒物中心或医生。。。如果你觉得不舒服 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P362: 脱下污染的衣服并洗净