CAS number：483367-10-8 molecular formula：C31H32N6O2
Purmorphamine与Smo拮抗剂竞争性结合到Smoothened，并激活Smoothened，IC50约为1.5 μM，也诱导成骨细胞分化，EC50为1μM。An activator of the hedgehog (Hh) signaling pathway. Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM and also is an inducer of osteoblast differentiation with EC50 of 1 μM. An activator of the hedgehog (Hh) signaling pathway.
| Chinese alias | 9-环己基-N-[4-(4-吗啉基)苯基]-2-(1-萘氧基)-9H-嘌呤-6-胺 | 2-（1-萘基）-6-（4-吗啉苯胺）-9-环己嘌呤 | ||
| English alias | Shh Signaling Antagonist VI | 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine | ||
| CAS number | 483367-10-8 | molecular formula | C31H32N6O2 |
| molecular weight | 520.62 g/mol | Exact mass | - |
| PSA | 77.300 Ų | logp | 6.500 |
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