compound introduction
UK-5099 UK-5099 (PF-1005023) 是线粒体丙酮酸转运蛋白 (MPC) 的有效抑制剂， 抑制丙酮酸依赖性O2消耗的 IC50 值为50 nM。 application： UK-5099 has been used: as a mitochondrial pyruvate blocker to reduce pyruvate transportation into mitochondria in Roswell park memorial institute (RPMI) 1640 medium for prostatic cancer cell line culture in dimethyl sulfoxide (DMSO) stock, to study the effect of inhibiting pyruvate transport into mitochondria on pro-inflammatory responses in lipopolysaccharide activated macrophages in topical treatment in order to study its effect on hair cycle induction in experimental mice.
