SM-7368 是一种 NF-kB 抑制剂,靶向抑制下游的 MAPK p38。SM-7368 还抑制 TNF-α 诱导的 MMP-9 上调。SM-7368 可用于靶向 TNF-α 介导的肿瘤侵袭和转移的化疗研究。 SM-7368 is a potent NF-kB inhibitor that targets downstream of MAPK p38 activation. SM-7368 inhibits TNF-α-induced MMP-9 upregulation. SM-7368 can be used for the research of chemotherapies targeting TNF-α-mediated tumor invasion and metastasis
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SM 7368
Dangerous GoodsCAS number:380623-76-7 molecular formula:C10H5ClN4O5S
overview
compound introduction
Specs
| Chinese alias | 3-氯-4-硝基-N-(5-硝基-2-噻唑基)苯甲酰胺 | ||
| English alias | NF-B Activation Inhibitor III | 3-Chloro-4-nitro-N-(5-nitro-1,3-thiazol-2-yl)benzamide | NF kappa B Activation Inhibitor III | MS-24931 | NF-(c)AB Activation Inhibitor III | SCHEMBL159312 | SM-7368, >=98% (HPLC) | 3-Chloro-4-nitro-N-(5-nitrothiazol-2-yl)b | ||
| CAS number | 380623-76-7 | molecular formula | C10H5ClN4O5S |
| molecular weight | 328.69 g/mol | Exact mass | ≥99% |
| PSA | 162.000 Ų | logp | 2.700 |
numbering system
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physicochemical properties
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Safety information
pictogram:
GHS05 , GHS07
Signal word:
Danger
Hazard Statement:
H302: 吞食有害 H318: 造成严重的眼睛损伤
Statement of Preventive Measures:
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时,请勿进食、饮水或吸烟。 P330: 漱口 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽:请寻求医疗帮助。 P305+P354+P338: 如果进入眼睛:立即用水冲洗几分钟。取下隐形眼镜(如果有的话),并且操作简单。继续冲洗。 P317: 寻求紧急医疗救助。
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MSDS
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