Information ASLAN003 ASLAN003 (LAS 186323) is a potent and orally active inhibitor of DHODH (Dihydroorotate dehydrogenase) with IC50 of 35 nM for human DHODH enzyme activity. ASLAN003 impairs protein synthesis and induces the differentiation and apoptosis transcriptional program in acute myeloid leukemia (AML) cells via activation of AP-1 transcription factors. Targets AP-1 ; human DHODH (Cell-free assay) ; 35 nM In vitro ASLAN003 is a highly potent dihydroorotate dehydrogenase inhibitor that induces differentiation, as well as reducing cell proliferation and viability, of AML cell lines and primary AML blasts including chemoresistant cells. Apoptotic pathways are triggered by ASLAN003, and this drug also significantly inhibits protein synthesis and activates AP-1 transcription, contributing to its capacity to promote differentiation. In vivo ASLAN003 substantially reduces leukemic burden and prolongs survival in AML xenograft mice and AML patient-derived xenograft models. ASLAN003 has no evident effect on normal hematopoietic cells and exhibits excellent safety profiles in mice, even after a prolonged period of administration. Cell Research(from reference) Cell lines：MOLM-14 cells, KG-1 cells Concentrations：1 μM, 2 μM Incubation Time：1 h
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ASLAN003
Dangerous GoodsCAS number：1035688-66-4 molecular formula：C19H14F2N2O3
overview
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Specs
| Chinese alias | - | ||
| English alias | 2-[2,6-difluoro-4-(3-methoxyphenyl)anilino]pyridine-3-carboxylic acid | ASALN003 | UNII-I58WE41H6X | MFCD32215342 | GLXC-26306 | BDBM119812 | AI3-27396 | SY270741 | 1035688-66-4 | CAS-135-23-9 | MS-25575 | 2-[(3,5-difluoro-3'-methoxy-4-biphenylyl)amino]ni | ||
| CAS number | 1035688-66-4 | molecular formula | C19H14F2N2O3 |
| molecular weight | 356.32 g/mol | Exact mass | - |
| PSA | 71.500 Ų | logp | 4.311 |
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physicochemical properties
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
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