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PF-06840003

Dangerous Goods

CAS number：198474-05-4    molecular formula：C12H9FN2O2

overview
Specs
numbering system
physicochemical properties
Safety information
Production methods and uses
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overview

compound introduction

PF-06840003 (EOS200271) 是一种选择性 IDO-1 抑制剂，抑制 hIDO-1， dIDO-1，和 mIDO-1 的IC50 分别为 0.41 μM， 0.59 μM，和 1.5 μM。 尽管它对hIDO1仅具有中等抑制作用（IC50=0.41 μM），但它能与hIDO-1紧密结合，和hIDO-1之间形成高密度的氢键，所以PF-06840003是一个非常高效的化合物(LE 0.53, LipE 5.1)。

Specs

Chinese alias-
English aliasAKOS027252536 | EOS200271 | EOS-200271 | Q420698 | US9603836, Compound 1 | GTPL9565 | A925049 | s8657 | SCHEMBL5463464 | EOS200271; EOS-200271; EOS 200271; PF 06840003; PF06840003 | EX-A1186 | NSC-796100 | BP168137 | DTXSID00630149 | SB22834 | AMY445 | 2,
CAS number198474-05-4molecular formulaC12H9FN2O2
molecular weight232.21 g/molExact mass-
PSA62.000 Ųlogp0.900

numbering system

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physicochemical properties

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Safety information

pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

Production methods and uses

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MSDS

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