CAS number：1628260-79-6 molecular formula：C30H33FN8O2S
产品介绍： Ziritaxestat (GLPG1690)是选择性的自毒素抑制剂，IC50为131 nM，Ki值为15 nM。 Information Ziritaxestat (GLPG1690) Ziritaxestat (GLPG1690) is a selective autotaxin inhibitor with an IC50 of 131 nM and Ki of 15 nM. Targets Autotaxin 15 nM(Ki) In vivo Ziritaxestat (GLPG1690) decreases LPA levels in a sustainable manner, in mouse plasma, from a dose of 3 mg/kg onward. It demonstrates significant activity in the mouse BLM-induced fibrosis model at doses of 10 and 30 mg/kg twice a day.
| Chinese alias | 齐利他司他 (GLPG1690) | ||
| English alias | (2-Amino-4-oxo-4,5-dihydro-1,3-thiazol-5-yl)acetic acid # | AC-36149 | GLPG-1690(Ziritaxestat) | MFCD31544330 | Ziritaxestat [USAN] | WHO 11017 | GTPL9561 | 2-[[2-Ethyl-8-Methyl-6-[4-[2-(3-Oxidanylazetidin-1-Yl)-2-Oxidanylidene-Ethyl]piperazin-1-Yl]imidaz | ||
| CAS number | 1628260-79-6 | molecular formula | C30H33FN8O2S |
| molecular weight | 588.7 g/mol | Exact mass | - |
| PSA | 132.000 Ų | logp | 4.8 |
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