compound introduction
Pardoprunox hydrochloride (DU-126891, SME-308)是一种有效的部分 dopamine D2 receptor 的激动剂，对应的pEC50值为8.0，也是诱导 [35S]GTPγS binding 的部分激动剂，对应的pEC50值为9.2，和 serotonin 5-HT1A receptor 的激动剂，pEC50值为6.3。 Information Pardoprunox hydrochloride (DU-126891, SME-308) is a potent but partialdopamine D2 receptoragonist with pEC50 of 8.0, and a partial agonist in the induction of[35S]GTPγS bindingwith pEC50 of 9.2 and aserotonin 5-HT1A receptoragonist, with pEC50 of 6.3, respectively. Targets [ 35 S]GTPγS binding (Cell-free assay); D2 receptor (Cell-free assay); 5-HT1A receptor (Cell-free assay) 9.2(pEC50); 8.0(pEC50); 6.3(pEC50)
