Lanicemine (AZD6765) dihydrochloride is a low-trapping NMDA channel blocker ( K i of 0.56-2.1 μM for NMDA receptor ; IC 50 s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects In Vivo Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects . Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats Dosage: 3, 10 or 30 mg/kg Administration: Intraperitoneal Result: Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity. Form:Solid IC50& Target:NMDA receptor
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Lanicemine dihydrochloride
Dangerous GoodsCAS number：153322-06-6 molecular formula：C13H16Cl2N2
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| Chinese alias | 拉尼西明二盐酸盐 | ||
| English alias | (1S)-1-phenyl-2-(pyridin-2-yl)ethan-1-amine dihydrochloride | (S)-1-Phenyl-2-(pyridin-2-yl)ethanamine dihydrochloride | Lanicemine dihydrochloride | FPL 15896AR | UNII-59E712CNQR | (1S)-1-phenyl-2-pyridin-2-ylethanamine;dihydrochloride | ARL 15896AR | 2-P | ||
| CAS number | 153322-06-6 | molecular formula | C13H16Cl2N2 |
| molecular weight | 271.19 g/mol | Exact mass | ≥99% |
| PSA | 38.900 Ų | logp | - |
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Safety information
pictogram：
GHS06
Signal word：
Danger
Hazard Statement：
H301: 吞咽会中毒
Statement of Preventive Measures：
P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P316: 如果吞咽：立即寻求紧急医疗救助。
WGK Germany：
3
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