CAS number：212844-54-7 molecular formula：C20H25ClN6O3
产品介绍 : Purvalanol B (NG 95) 是一种有效、选择性、可逆和 ATP 竞争性的 CDK 抑制剂，对 cdc2-cyclin B，CDK2-cyclin A，CDK2-cyclin E 的 IC50 值分别为 6 nM、6 nM、9 nM、6 nM 和 CDK5-p35，分别。 Purvalanol B 在一系列其他蛋白激酶 (IC50>1000 nM) 中显示出对 CDK 的选择性。Purvalanol B 抑制耐氯喹菌株 P. falciparum 的生长。 Product Application： SB-216763 was used to inhibit GSK-3β in human brain microvascular endothelial cell line and colorectal cancer cells.
| Chinese alias | - | ||
| English alias | BDBM7478 | PURVALANOL | 2-chloro-4-[[2-[[(2R)-1-hydroxy-3-methylbutan-2-yl]amino]-9-propan-2-ylpurin-6-yl]amino]benzoic acid | HMS3412L09 | 2-chloro-4-[(2-{[(2R)-1-hydroxy-3-methylbutan-2-yl]amino}-9-(propan-2-yl)-9H-purin-6-yl)amino]benzoic acid | NCGC00 | ||
| CAS number | 212844-54-7 | molecular formula | C20H25ClN6O3 |
| molecular weight | 432.9 g/mol | Exact mass | - |
| PSA | 125.000 Ų | logp | 3.800 |
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