PAMAM树状聚合物是一种具有大量末端基团的对称聚合物，由于其生物相容性和亲和性，可以轻易地与生物分子结合。这些树枝状聚合物具有多价表面，其中包含包膜和与树枝相附的核内各种活性位点。它们是高度分支的纳米级聚合物，广泛用于在生物医学领域的靶向给药。 应用 PAMAM树状聚合物可作为核酸递送的转染剂使用。例如，它可用于靶向肿瘤坏死因子(TNF)的siRNA的肺部给药。 PAMAM dendrimer is a symmetrical polymer with a large number of terminal groups that can easily bind to biomolecules due to their biocompatibility and affinity. These dendrimers have a multivalent surface that contains envelopes and various active sites at the core with the attached dendrons. They are highly branched nanoscale polymers that are extensively used in the field of biomedicine for targeted drug delivery. Application PAMAM dendrimers can be used as transfection agents for the delivery of nucleic acids. For example, it can be used in the pulmonary delivery of siRNA directed against tumor necrosis factor (TNF).
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PAMAM dendrimer, ethylenediamine core, generation 3.0 solution
Dangerous GoodsCAS number：153891-46-4 molecular formula：[NH2(CH2)2NH2]:(G=3);dendri PAMAM(NH2)32
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | Starburst PAMAM-G 3 | ||
| CAS number | 153891-46-4 | molecular formula | [NH2(CH2)2NH2]:(G=3);dendri PAMAM(NH2)32 |
| molecular weight | 6908.84 g/mol | Exact mass | 20wt. % in methanol |
| PSA | - | logp | - |
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physicochemical properties
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Safety information
pictogram：
GHS06 , GHS08 , GHS02
Signal word：
Danger
Hazard Statement：
H225: 高度易燃的液体和蒸气 H370: 对器官造成损害 H301+H311+H331: 吞咽、皮肤接触或吸入中毒。
Statement of Preventive Measures：
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P301+P310: 如误吞咽：立即呼叫急救中心/医生。 P210: 远离热源，热表面，火花，明火和其他点火源。 - 禁止抽烟。 P233: 保持容器密闭。 P303+P361+P353: 如皮肤（或头发）沾染：立即脱掉所有沾染的衣服。用水清洗皮肤/淋浴。
UN Number：
1230
Packing Group：
II
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