(E/Z)-Endoxifen

Dangerous Goods

CAS number：110025-28-0 molecular formula：C25H27NO2

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

Product description： (E/Z)-Endoxifen is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has an approximately 100-fold greater affinity for estrogen receptors than tamoxifen. As the efficient conversion of tamoxifen to endoxifen depends on CYP2D6, polymorphisms in this CYP isoform can impact the effectiveness of TMX treatment.

Specs

Chinese alias	(E / Z)-4-[1-[4-[2-(甲基氨基)乙氧基]苯基] -2-苯基-1-丁-1-基]-苯酚
English alias	BCP18474 \| BS-41687 \| 4OHNDtam \| UNII-HB2U71MNOT \| 4-[1-[4-[2-(METHYLAMINO)ETHOXY]PHENYL]-2-PHENYL-1-BUTENYL]PHENOL \| Endoxifen, (E)- \| Phenol, 4-(1-(4-(2-(methylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)- \| Q26998030 \| Phenol,4-[1-[4-[2-(methylamino)ethoxy
CAS number	110025-28-0	molecular formula	C25H27NO2
molecular weight	373.49 g/mol	Exact mass	≥98%(HPLC)
PSA	41.500 Å²	logp	6.300

numbering system

No numbering system information yet

physicochemical properties

No physical and chemical property information yet

Safety information

pictogram：

GHS08 , GHS07

Signal word：

Warning

Hazard Statement：

H413: 可能对水生生物造成长期的有害影响 H302: 吞食有害 H312: 皮肤接触有害 H332: 吸入有害 H302+H312+H332: 吞咽，皮肤接触或吸入有害。 H361: 怀疑破坏生育力或未出生的孩子

Statement of Preventive Measures：

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P