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Tenofovir alafenamide fumarate

Dangerous Goods

CAS number：379270-38-9    molecular formula：C25H33N6O9P

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overview

compound introduction

Tenofovir alafenamide (TAF, GS-7340) fumarate 是替诺福韦的前药，但可导致细胞内替诺福韦浓度明显升高，血清水平降低。Tenofovir alafenamide 是一种新型的核苷酸逆转录酶 nucleotide reverse transcriptase 的抑制剂，可用于治疗HIV-1感染。 Information Tenofovir alafenamide fumarate Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection. Targets reverse transcriptase

Specs

Chinese alias-
English aliasLH74NEA26W | SY003405 | Tenofovir Alafenamide fumarate | AS-56987 | L-Alanine, N-((S)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinyl)-, 1-methylethyl ester, (2E)-2-butenedioate (1:1) | 1422343-76-7 | GS-7340 (fumarate) | EN300-73
CAS number379270-38-9molecular formulaC25H33N6O9P
molecular weight592.54 g/molExact mass10mM in DMSO
PSA218.000 Ųlogp1.565

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Safety information

pictogram：
GHS08
Signal word：
Warning
Hazard Statement：
H373: 通过长时间或反复暴露对器官造成损害
Statement of Preventive Measures：
P501: 将内容物/容器处理到。。。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P319: 如果你感到不适，请寻求医疗帮助。

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