Pibrentasvir (ABT-530)

Dangerous Goods

CAS number：1353900-92-1 molecular formula：C57H65F5N10O8

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

Information Pibrentasvir (ABT-530) Pibrentasvir (ABT-530) is a novel and pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with EC50 ranging from 1.4 pM to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6. Targets GT5a (Cell-free assay); GT1a H77 (Cell-free assay); GT2b (Cell-free assay); GT4a (Cell-free assay); GT3a (Cell-free assay) 33615,1.4 pM(EC50); 1.8 pM(EC50); 1.9 pM(EC50); 1.9 pM(EC50); 2.1 pM(EC50) In vitro Pibrentasvir is a next-generation HCV NS5A inhibitor with potent and pan-genotypic activity, and it maintains activity against common amino acid substitutions of HCV genotypes 1 to 6 that are known to confer resistance to currently approved NS5A inhibitors. Cell Research(from reference) Cell lines：Huh-7 human hepatoma cell line, CEM-SS cells Incubation Time：6 days

Specs

Chinese alias	-
English alias	ABT 530 \| D10816 \| Dimethyl ((2S,2'S,3R,3'R)-((2S,2'S)-(((2R,5R)-1-(3,5-difluoro-4-(4-(4-fluorophenyl)piperidin-1-yl)phenyl)pyrrolidine-2,5-diyl)bis(5-fluoro-1H-benzo[d]imidazole-6,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methoxy-1-oxobutane-1,2-diyl))dica
CAS number	1353900-92-1	molecular formula	C57H65F5N10O8
molecular weight	1113.18 g/mol	Exact mass	-
PSA	200.000 Å²	logp	8.515

numbering system

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physicochemical properties

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Safety information

pictogram：

GHS07

Signal word：

Warning

Hazard Statement：

H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H413: 可能对水生生物造成长期的有害影响

Statement of Preventive Measures：

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P264: 处理后要彻底洗手。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。