Information Efinaconazole Efinaconazole (KP-103) is an inhibitor of 14 alpha-demethylase which is involved in the biosynthesis of ergosterol, a constituent of fungal cell membranes. Targets 14 alpha-demethylase In vitro In in vitro antifungal susceptibility tests, efinaconazole shows lower minimum inhibitory concentration (MIC) than terbinafine, ciclopirox, itraconazole and amorolfine. In vivo Efinaconazole is a topical antifungal, so it has relatively low systemic accumulation. The plasma half-life after 10 days of administration is 29.9 h. It has high plasma protein-binding affinity from 95.8 to 96.5%; primarily to albumin, a1-acid glycoprotein and γ-globulin. Efinaconazole is metabolized extensively through oxidative and reductive processes resulting in a sole H3 metabolite. It may also undergo glucuronidation. Efinaconazole does not have significant interactions with CYP450 enzymes in the liver. CYP2C8, CYP2C9, CYP2C19 and CYP3A4 are inhibited by efinaconazole at concentrations higher than the systemic concentrations achieved clinically.
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Efinaconazole
Dangerous GoodsCAS number：164650-44-6 molecular formula：C18H22F2N4O
overview
compound introduction
Specs
| Chinese alias | 艾菲康唑 | 埃非那康唑 | (αR,βR)-, α-(2,4-二氟苯基)-β-甲基-4-亚甲基-α-(1H-1,2 ,4-三唑-1-基甲基)-1-哌啶乙醇 | (2R,3R)-2-(2,4-二氟苯基)-3-(4-亚甲基哌啶-1-基)-1-(1H-1,2,4-三唑-1-基)丁-2-醇 | ||
| English alias | KP103 | KP-103 | NCGC00390702-02 | HY-15660 | CCG-268012 | (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidine-1-yl)-1-(1H-1,2,4-triazole-1-yl)butane-2-ol | EFINACONAZOLE | MFCD00936406 | D01AC19 | NCGC00390702-01 | Efinaconazole [USAN:INN] | EFINACON | ||
| CAS number | 164650-44-6 | molecular formula | C18H22F2N4O |
| molecular weight | 348.39 g/mol | Exact mass | - |
| PSA | 54.200 Ų | logp | 2 |
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physicochemical properties
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Safety information
pictogram：
GHS08
Signal word：
Warning
Hazard Statement：
H361: 怀疑破坏生育力或未出生的孩子
Statement of Preventive Measures：
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P201: 使用前获取特殊说明 P308+P313: 如接触到或有疑虑：求医/就诊。 P202: 在阅读并理解所有安全预防措施之前，不要进行操作。
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MSDS
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