DAG激酶抑制剂是DGK（二酰基甘油激酶； DAG激酶）的抑制剂，可用于阐明蛋白激酶C（PKC）的作用。据报道，DAG激酶抑制剂还可以在一些系统中抑制DGK，例如分离的血小板膜，完整的血小板和幽灵红细胞。其他报告显示以浓度依赖性方式抑制。如使用无细胞系统报道的那样，DAG激酶抑制剂还可能抑制其他途径，例如NADPH，并可能干扰脂质介导的氧化酶成分的组装过程。据报道，这种特定的同工型R59949可能表现出对DGK-α的选择性抑制。 DAG Kinase Inhibitor is an inhibitor of DGK (Diacylglycerol kinase; DAG Kinase) and is useful for elucidating the roles of protein kinase C (PKC). DAG Kinase Inhibitor has also been reported to inhibit DGK in several systems such as isolated platelet membranes, whole platelets and ghost erythrocytes. Additional reports have shown to inhibit in a concentration dependent manner. DAG Kinase Inhibitor may also inhibit other pathways such as NADPH and potentially interfere with the lipid-mediated assembly process of oxidase components as reported using a cell-free system. This particular isoform, R59949, has been reported to potentially exhibit selective inhibition of DGK-α.
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DAG Kinase Inhibitor II
Dangerous GoodsCAS number：120166-69-0 molecular formula：C28H25F2N3OS
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | FT-0759122 | AKOS040747334 | 3-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-2-sulfanylidene-1,2,3,4-tetrahydroquinazolin-4-one | STO500 | BDBM43868 | R59949 | R-59949 | 3-[2-(4-[bis-(4-fluorophenyl)methylene]-1-piperidinyl)ethyl] -2,3-dihyd | ||
| CAS number | 120166-69-0 | molecular formula | C28H25F2N3OS |
| molecular weight | 489.58 g/mol | Exact mass | - |
| PSA | 67.700 Ų | logp | 5.600 |
numbering system
No numbering system information yet
physicochemical properties
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移
WGK Germany：
3
Personal protective equipment：
dust mask type N95 (US)， Eyeshields， Gloves
Production methods and uses
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Related
upstream information
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downstream information
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MSDS
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