Information Decursinol angelate Decursinol angelate is a cytotoxic and protein kinase C activating agent from the root of Angelica gigas. Targets PKC In vitro Decursinol angelate (DA) blocks PGE2-induced activation of the EP2 receptor signaling pathway, including the activation of PKA and the phosphorylation of CREB. Decursinol angelate also inhibits PGE2-induced expression of cyclooxygenase-2 and the activation of the Ras/Raf/Erk pathway, which activates downstream targets for cell survival. Decursinol angelate greatly reduces the PGE2-induced activation of NF-κB p50 and p65 subunits. It has been reported to suppress the growth of estrogen-stimulated and estrogen-independent growth and survival of breast cancer MCF-7 and MDA-MB-231 cells. Decursinol angelate also suppresses the growth of cancer cells through the inhibition of phosphatidylinositol 3\'-kinase (PI3K)/Akt, extracellular-signal-regulated kinase (Erk) and nuclear factor-κB (NFκB). Decursinol angelate has anti-leukemic activity through the suppression of protein kinase C activation in human leukemia cells. In vivo Decursinol angelate has anti-angiogenic activity both in vitro and in vivo. Cell Research(from reference) Cell lines：MCF-7 cells Concentrations：10 μM, 20 μM, 50 μM Incubation Time：24 hours
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Decursinol angelate
Dangerous GoodsCAS number：130848-06-5 molecular formula：C19H20O5
overview
compound introduction
Specs
| Chinese alias | 紫花地黄醇酯 | ||
| English alias | DTXSID401315533 | Decursinolangelate | MS-24919 | E80810 | HY-N4322 | [(3S)-2,2-dimethyl-8-oxo-3,4-dihydropyrano[3,2-g]chromen-3-yl] (Z)-2-methylbut-2-enoate | UNII-LXU5241LCL | (S)-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-7-yl (Z)-2-meth | ||
| CAS number | 130848-06-5 | molecular formula | C19H20O5 |
| molecular weight | 328.36 g/mol | Exact mass | 10mM in DMSO |
| PSA | 61.800 Ų | logp | 3.955 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
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MSDS
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130848-06-5 | Decursinol angelate.pdf
