Capmatinib (INCB28060)

Dangerous Goods

CAS number：1029712-80-8 molecular formula：C23H17FN6O

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

INCB28060是高活性c-MET口服活性抑制剂，IC50为0.13 nM。A novel inhibitor of Met (IC50 = 0.13 nM) Capmatinib (INCB28060) is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM in a cell-free assay, inactive against RONβ, as well as EGFR and HER-3. A novel inhibitor of Met (IC50 = 0.13 nM)

Specs

Chinese alias	苯扎米特 \| 卡马替尼
English alias	INCB-28060 \| INC-280 \| AMY18553 \| CCG-268791 \| HY-13404 \| O-(4-(dimethylsulfamoyl)phenyl) O,O-dimethyl thiophosphate \| 2-fluoro-n-methyl-4-[7-(quinolin-6-ylmethyl)imidazolo[1,2-b][1,2,4]triazin-2-yl]benzamide \| capmatinib \| J-509516 \| 2-fluoro-N-methyl-4-
CAS number	1029712-80-8	molecular formula	C23H17FN6O
molecular weight	412.42 g/mol	Exact mass	-
PSA	85.100 Å²	logp	2.9

numbering system

No numbering system information yet

physicochemical properties

No physical and chemical property information yet

Safety information

pictogram：

GHS06 , GHS08 , GHS09

Signal word：

Danger

Hazard Statement：

H301: 吞咽会中毒 H373: 通过长时间或反复暴露对器官造成损害 H411: 对水生生物有毒并具有长期持续影响 H360: 可能损害生育力或未出生的孩子

Statement of Preventive Measures：

P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P391: 收集溢出物 P330: 漱口 P203: 使用前，获取、阅读并遵守所有安全说明。 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 P318: 如果暴