compound introduction
F16是一种细胞可渗透的，荧光的，离域的亲脂性阳离子化合物，可充当线粒体毒素，并具有诱导肿瘤细胞凋亡和坏死的双重能力。F16优先积累在线粒体中，抑制氧化磷酸化并导致线粒体跨膜去极化。F16的掺入和定位可通过其荧光特性轻松监控。 说明： F16 是 neu 过表达细胞的有效生长抑制剂，还可以选择性抑制乳腺上皮以及多种小鼠乳腺肿瘤和人乳腺癌细胞系的增殖。F16 是线粒体毒性化合物，根据靶癌细胞的遗传背景触发凋亡或坏死。 F16 is a cell-permeable, fluorogenic, delocalized lipophilic cationic compound that acts as a mitochondrial toxin and possesses the dual ability to induce apoptosis as well as necrosis in tumor cells. F16 preferentially accumulates in mitochondria, inhibits oxidative phosphorylation and causes mitochondrial transmembrane depolarization. The incorporation and localization of F16 can be easily monitored by its fluorescence property.
