CAS number：1049741-03-8 molecular formula：C₃₂H₃₂F₃N₃O₂・2HCl・1/2H₂O
TNF-α抑制剂是一种细胞可渗透的吲哚基-色酮化合物，据报道可通过与TNF-α三聚体非共价结合而迅速失活TNF-α，促进亚基解离并阻止TNF-α与其受体结合。另外据报道在HeLa细胞中选择性抑制TNF-α-，但不抑制IL-1β诱导的Iκβ-α降解。 TNF-α Inhibitor is a cell-permeable indolyl-chromenone compound reported to rapidly inactivate TNF-α via non-covalently binding to the TNF-α trimer, promoting subunit dissociation and preventing TNF-α binding to its receptor. Additionally reported to selectively inhibit TNF-α-, but not IL-1β-induced Iκβ-α degradation in HeLa cells.
| Chinese alias | - | ||
| English alias | 6,7-Dimethyl-3-((methyl-(2-(methyl-(1-(3-trifluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCl | ||
| CAS number | 1049741-03-8 | molecular formula | C₃₂H₃₂F₃N₃O₂・2HCl・1/2H₂O |
| molecular weight | 629.6 g/mol | Exact mass | ≥95% |
| PSA | - | logp | - |
No numbering system information yet
No physical and chemical property information yet
No production method and use information yet
No upstream information yet
No downstream information yet
