FLLL32，一种姜黄素的合成类似物，是 JAK2/STAT3 的双重抑制剂，具有抗肿瘤癌活性。FLLL32 作用于乳腺癌细胞，可抑制 IFNα 和 IL-6 诱导的 STAT3 磷酸化。 Information FLLL32 is a potentJAK2/STAT3inhibitor withIC50of Targets JAK2 In vitro In MDA-MB-231 breast and PANC-1 pancreatic cancer cells, FLLL32 downregulates STAT3 phosphorylation and DNA-binding activity. In MDA-MB-231 cells, FLLL32 inhibit the formation of colonies and cell invasion. In human multiple myeloma, glioblastoma, liver cancer, and colorectal cancer cell lines, FLLL32 also leads to the inhibition of cell proliferation and the induction of caspase-3 and PARP cleavages. In vivo In MDA-MB-231 xenografted mice, FLLL32 (50 mg/kg, i.p.) significantly reduces tumor burdens. In mouse xenografts with OS-33 osteosarcoma cells, FLLL32 (50 mg/kg, i.p.) also inhibits tumor growth by targeting STAT3. Cell Research(from reference) Cell lines：MDA-MB-231 cell line Concentrations：~5 μM Incubation Time：72 hours
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FLLL32
Dangerous GoodsCAS number：1226895-15-3 molecular formula：C28H32O6
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | (2E,2'E)-1,1'-cyclohexylidenebis[3-(3,4-dimethoxyphenyl)-2-propen-1-one | ||
| CAS number | 1226895-15-3 | molecular formula | C28H32O6 |
| molecular weight | 464.55 g/mol | Exact mass | 10mM in DMSO |
| PSA | 71.100 Ų | logp | 5.800 |
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physicochemical properties
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Safety information
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
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