compound introduction
SEC inhibitor KL-1 (KL-1) 是一种有效的 super elongation complex (SEC) 的选择性抑制剂，可破坏SEC支架蛋白AFF4与P-TEFb之间的相互作用，从而导致自启动子近端暂停位点的Pol II释放受损和进行性转录延伸的平均速率的降低。KL-1 对AFF4-CCNT1相互作用起到剂量依赖性的抑制作用，其Ki值为3.48 μM。 Information SEC inhibitor KL-1 (KL-1) is a potent and selective inhibitor ofsuper elongation complex (SEC)that disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with Ki of 3.48 μM.
