Information UF010 is a class I HDAC-selective inhibitor with IC50 values of 0.5 nM, 0.1 nM, 0.06 nM, 1.5 nM, 9.1 nM and 15.3 nM for HDAC1, HDAC2, HDAC3, HDAC8, HDAC6 and HDAC10, respectively. Targets HDAC3 (Cell-free assay); HDAC2 (Cell-free assay); HDAC1 (Cell-free assay); HDAC8 (Cell-free assay); HDAC6 (Cell-free assay) 31045,0.06 nM; 0.1 nM; 0.5 nM; 1.5 nM; 9.1 nM In vitro In Cell-cycle analysis using MDA-MB-231 cells, UF010 mainly blocks G1/S transition with an increased G1 cell population and a reduced cell population in the S phase in a dose-dependent manner. UF010 has a half-life of 15.8 hr in cell culture medium containing 10% fetal bovine serum. Cell Research(from reference) Cell lines：HCT116 cells and A549 cells Concentrations：2 μM Incubation Time：1 h
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UF010
Dangerous GoodsCAS number：537672-41-6 molecular formula：C11H15BrN2O
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | Benzoic acid,4-bromo-,2-butylhydrazide | 4-Bromo-benzoic acid 2-butylhydrazide | 4-bromo-N'-butylbenzohydrazide | ||
| CAS number | 537672-41-6 | molecular formula | C11H15BrN2O |
| molecular weight | 271.15 g/mol | Exact mass | 10mM in DMSO |
| PSA | 41.100 Ų | logp | 2.623 |
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Safety information
Signal word：
Warning
Hazard Statement：
H302: 吞食有害
Statement of Preventive Measures：
P301+P312+P330: 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口
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