compound introduction
应用 HOBt和HOAt的非爆炸性替代品，性能与HOAt至少相当在空间要求严格的肽键形成中性能胜过HOAt与碳二亚胺介导的过程相兼容；溶液和固相肽偶联；片段缩合反应中的差向异构现象少于HOBtK盐特别适用于在弱酸不稳定的树脂（如2-氯三苯甲基）上进行肽偶联；由于其具有更强的碱性，因此使得肽从树脂上脱离的概率降至最低甚至没有K盐的熔点高于OxymaPure Description Non-explosive replacement for HOBt and HOAt with at least comparable performance to HOAtOutperforms HOAt in sterically demanding peptide bond formationsCompatible with carbodiimide-mediated; solution and solid phase peptide coupling;Less epimerization than HOBt in fragment condensation reactionsK-salt especially useful in peptide coupling on mild acid-labile resins such as 2-chlorotrityl; leading to minimal to no cleavage of the peptide from the resin due to its more alkaline characterK-salt has a higher melting point than OxymaPure
