C527 is a is a pan DUB enzyme inhibitor, with a high potency for the USP1/UAF1 complex ( IC 50 =0.88 μM). In Vitro Pretreatment of USP1/UAF1 with C527 resulted in inhibition of its enzyme activity with an IC 50 of 0.88±0.03 μM. C527 inhibits the DUB activity of the USP12/USP46 complex and other DUB enzymes in vitro . However, the IC 50 of C527 for these DUB enzymes was higher in comparison with USP1/UAF1 complex. C527 has considerably less inhibitory effect on UCH-L1 and UCH-L3, a different subclass of DUB enzymes. C527 treatments causes an increase in the levels of Ub-FANCD2 and Ub-FANCI. Pretreatment of cells with the C527 causes an enhancement in the cytoxicity of mitomycin C and camptothecin. C527 treatments lead to an increase in ubiquitinated forms of FANCD2 and FANCI, cause a decrease in homologous recombination activity, and sensitize cells to DNA damaging agents. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:0.88 μM (USP1)
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C527
Dangerous GoodsCAS number：192718-06-2 molecular formula：C17H8FNO3
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Specs
| Chinese alias | - | ||
| English alias | MFCD01033540 | Z56772527 | EN300-17988316 | 2-(4-fluorophenyl)-4H,9H-naphtho[2,3-d][1,3]oxazole-4,9-dione | 2-(4-Fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione | 2-(4-fluoro-phenyl)-naphtho[2,3-d]oxazole-4,9-dione | 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4 | ||
| CAS number | 192718-06-2 | molecular formula | C17H8FNO3 |
| molecular weight | 293.25 g/mol | Exact mass | ≥99% |
| PSA | 60.200 Ų | logp | 3.700 |
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H302: 吞食有害
Statement of Preventive Measures：
P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P317: 如果被吞咽：请寻求医疗帮助。
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