McN3716 is a carnitine palmitoyltransferase I ( CPT-1 ) inhibitor. Form:Solid IC50& Target:Carnitine palmitoyltransferase I (CPT-1) In Vivo:Inhibition of brain mitochondrial β-oxidation by McN3716 (Methyl palmoxirate, MEP) significantly reduces the levels of all measured HETE and epoxytrienoic acids (EET), nonenzymatic auto-oxidative metabolites of ARA, by 23% to 44% and 32% to 50% compared with vehicle-injected rats, respectively, except for 15-HETE which was unaffected. There is a significant 34% reduction in the level of 6-keto-PGF 1α , a byproduct of PGI 2 (prostacyclin) in McN3716-treated rats. Similarly, the brain level of hydroxyeicosapentaenoic acids, nonenzymatic auto-oxidative metabolites of EPA, is reduced by 35% to 76% upon McN3716 treatment relative to vehicle [1] . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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McN3716
Dangerous GoodsCAS number：69207-52-9 molecular formula：C18H34O3
overview
compound introduction
Specs
| Chinese alias | 麦克纳利3716 | ||
| English alias | Methyl palmoxirate; NSC359682 | MS-24298 | BCP30486 | AKOS040733698 | 2-Tetradecyl-2-oxiranecarboxylic acid methyl ester | Methyl palmoxirate [USAN] | NPL6006Y4B | 2-Tetradecyl-oxirane-2-carboxylic acid methyl ester | SCHEMBL243423 | Methyl 2-tetradecylgl | ||
| CAS number | 69207-52-9 | molecular formula | C18H34O3 |
| molecular weight | 298.46 g/mol | Exact mass | - |
| PSA | 38.800 Ų | logp | 6.800 |
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physicochemical properties
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移
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