Dichlorophenyl-ABA is an inhibitor of transthyretin (TTR) amyloid fibril formation , inhibiting aggregate formation in more than 80% in TTR L55P-expressing cells In Vitro Dichlorophenyl-ABA (DCPA) is able to prevent L55P aggregate formation in the conditioned medium. With regard to the ultrastructural analysis, Dichlorophenyl-ABA does not show an inhibitory effect as high as DFPB and benzoxazole, indicating that the Y78F mutant may not be as sensitive to this drug as TTR L55P and V30M are. Dichlorophenyl-ABA is the best stabilizers of V30M tetramers in plasma from carriers of this mutant, and clearly inhibit aggregation in the cellular system. Therefore Dichlorophenyl-ABA is promising for the treatment of valine at position 30 (V30M)-associated familial amyloidotic polyneuropathy (FAP) but need to undergo further stages of drug development to overcome their toxicity. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Transthyretin (TTR) amyloid fibril formation
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Dichlorophenyl-ABA
Dangerous GoodsCAS number：18201-65-5 molecular formula：C13H9Cl2NO2
overview
compound introduction
Specs
| Chinese alias | 二氯苯基脱落酸 | ||
| English alias | benzoic acid, 2-[(3,5-dichlorophenyl)amino]- | benzoic acid,2-[(3,5-dichlorophenyl)amino]- | 2-[(3,5-dichlorophenyl)amino]benzoic acid | 2-(3,5-dichloroanilino)benzoic acid | Dichlorophenyl ABA | Benzoic acid, 2-[(3,5-dichlorophenyl)amino]- (9CI) | AKOS01 | ||
| CAS number | 18201-65-5 | molecular formula | C13H9Cl2NO2 |
| molecular weight | 282.12 g/mol | Exact mass | ≥99% |
| PSA | 49.300 Ų | logp | 6.200 |
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physicochemical properties
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移
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