Saxagliptin hydrate是一种有效，选择性，可逆，竞争性和具有口服活性的二肽基肽酶 4 (DPP-4) 抑制剂。可用于 2 型糖尿病的研究。 Saxagliptin: A Long-Acting Dipeptidyl Peptidase-4 (DPP-4) Enzyme Inhibitor Saxagliptin is a long-acting dipeptidyl peptidase-4 (DPP-4) enzyme inhibitor which is a new class of anti-hyperglycemic agents. Released into the small intestine in response meals, incretins such as Glukagon-like peptide-1 (GLP-1) and glucose-dependent insulin tropic polypeptide (GIP) are known to be gastrointestinal hormones that promote insulin secretion and suppress Glukagon secretion in a glucose concentration-dependent manner. Saxagliptin inhibits the activity of DPP-4 that degrades and inactivates GLP-1 and GIP. Through this inhibition, saxagliptin increases the blood concentration of active GLP-1, and exerts its hypoglycemic effect through increasing insulin secretion and reducing Glukagon secretion. (The product is for research purpose only.)
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Saxagliptin Hydrate
Dangerous GoodsCAS number：945667-22-1 molecular formula：C18H27N3O3
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrate(1:1) | N0424 | CHEBI:71271 | QTERNMET COMPONENT SAXAGLIPTIN | Saxagliptin [USAN] | Saxagliptin hydrate | SAXAGLIPTIN MONOHYDRATE [ | ||
| CAS number | 945667-22-1 | molecular formula | C18H27N3O3 |
| molecular weight | 333.43 g/mol | Exact mass | 10mM in DMSO |
| PSA | 91.400 Ų | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS08
Signal word：
Danger
Hazard Statement：
H317: 可能引起皮肤过敏反应 H334: 吸入可能引起过敏或哮喘病症状或呼吸困难 H372: 通过长时间或反复暴露对器官造成损害 H361: 怀疑破坏生育力或未出生的孩子
Statement of Preventive Measures：
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P342+P311: 如有呼吸系统病症：呼叫急救中心/医生。 P302+P352: 如皮肤沾染：用水充分清洗。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P284: 如果通风不良，请佩戴呼吸防护装置。 P201: 使用前获取特殊说明 P308+P313: 如接触到或有疑虑：求医/就诊。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适
Production methods and uses
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Related
upstream information
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downstream information
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MSDS
Found 1 shareMSDS
945667-22-1 | Saxagliptin monohydrate CRS, EuropeanPharmacopoeia (EP) Reference Standard.pdf
