双辛基马来酰亚胺是有效的，选择性的蛋白激酶C（PKC）抑制剂。它们在结构上与天然存在的分子星形孢菌素相似，但相对于其他蛋白激酶，它们对PKC的选择性更高。双辛基马来酰亚胺用于选择性探测PKC介导的激素，细胞因子和生长因子信号的转导途径。双辛基马来酰亚胺通过与催化亚基相互作用抑制PKC。抑制作用与ATP竞争。对类似物的结构-活性关系的研究表明，吲哚氮上的阳离子取代基增加了其作为PKC抑制剂的能力。 Bisindolylmaleimides are potent, selective inhibitors of protein kinase C (PKC). They are structurally similar to the naturally occurring molecule, staurosporine, but they are more selective for PKC over other protein kinases. Bisindolylmaleimides are used to selectively probe for PKC-mediated pathways for transduction of hormone, cytokine, and growth factor signals. Bisindolylmaleimides inhibit PKC by interacting with the catalytic subunit. Inhibition is competitive with ATP. Studies of structure-activity relationships of analogs indicate that cationic substituents at the indole nitrogen increase the potency as an inhibitor of PKC.
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
3-(1H-indol-3-yl)-4-[1-(3-piperazin-1-ylpropyl)indol-3-yl]pyrrole-2,5-dione
Dangerous GoodsCAS number：137592-47-3 molecular formula：C27H27N5O2
overview
compound introduction
Specs
| Chinese alias | 3-(1H-吲哚-3-基)-4-{1-[3-(1-哌嗪基)丙基]-1H-吲哚-3-基}-1H-吡咯-2,5-二酮 | ||
| English alias | 3-(1H-indol-3-yl)-4-[1-(3-piperazin-1-ylpropyl)indol-3-yl]pyrrole-2,5-dione | DTXSID40274364 | SCHEMBL7978092 | Bisindolylmaleimide VII, 96% (TLC), solid | BDBM2686 | Bisindolyl deriv. 24 | bisindolylmaleimide vii | 3-(1H-indol-3-yl)-4-(1-(3-(piperazin-1- | ||
| CAS number | 137592-47-3 | molecular formula | C27H27N5O2 |
| molecular weight | 453.5 | Exact mass | ≥96% |
| PSA | 82.2 | logp | 2.4 |
numbering system
| CAS | 137592-47-3 |
| Wikidata | Q82003731 |
| ChEMBL ID | CHEMBL446199 |
| PubChem CID | 2402 |
| Nikkaji Number | J1.479.496D |
| DSSTox Substance ID | DTXSID40274364 |
physicochemical properties
| XLogP3 | XLogP3-AA: 2.4 |
| 复杂性 | 822 |
| Exact Mass | 453.21647512 |
| 形式电荷 | 0 |
| 重原子计数 | 34 |
| Molecular Weight | 453.5 |
| Monoisotopic Mass | 453.21647512 |
| 可旋转键计数 | 6 |
| 氢键供体计数 | 3 |
| 氢键受体计数 | 4 |
| 共价键单元计数 | 1 |
| 同位素原子计数 | 0 |
| 拓扑极性表面积 | 82.2 Ų |
| 定义键立体中心计数 | 0 |
| 定义原子立体中心计数 | 0 |
| 未定义键立体中心计数 | 0 |
| 未定义原子手性中心计数 | 0 |
Safety information
WGK Germany：
3
Personal protective equipment：
Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter
Production methods and uses
purpose
工业应用参考：
工业分类参考：电气机械和器材制造业。
应用场景参考：常见于生产制造场景，可作为主料、辅料、添加剂或工艺辅助材料参与配方与加工流程 。
作用参考：可作为基础工业材料参与合成、提纯或改性过程，为后续产品制造和工艺放大提供支撑 。
选型提示：不同品牌和不同标准体系下的技术参数可能存在差异，应用前应优先核对规格、检测方法和质量要求 。
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
