compound introduction
VX-661是一种vertex衍生物，可校正F508del-CFTR转运，并可在体外增加F508del-CFTR蛋白的活性。 VX-661 is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.
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VX-661
Dangerous GoodsCAS number：1152311-62-0 molecular formula：C26H27F3N2O6
overview
Specs
| Chinese alias | 1-(2,2-二氟-1,3-苯并二氧戊环-5-基)-N-[1-[(2R)-2,3-二羟基丙基]-6-氟-2-(2-羟基-1,1-二甲基乙基)-1H-吲哚-5-基]-环丙烷甲酰胺 | ||
| English alias | 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)indol-5-yl]cyclopropane-1-carboxamide | EN300-7398484 | TRIKAFTA COMPONENT TEZACAFTOR | 1-(2,2-difluoro-1,3-dioxaindan-5-yl)-N-{1-[(2R)-2,3-dih | ||
| CAS number | 1152311-62-0 | molecular formula | C26H27F3N2O6 |
| molecular weight | 520.5 g/mol | Exact mass | - |
| PSA | 113.000 Ų | logp | 2.9 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS08
Signal word：
Danger
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H341: 怀疑引起遗传缺陷 H413: 可能对水生生物造成长期的有害影响 H317: 可能引起皮肤过敏反应 H334: 吸入可能引起过敏或哮喘病症状或呼吸困难 H370: 对器官造成损害 H361: 怀疑破坏生育力或未出生的孩子
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P342+P311: 如有呼吸系统病症：呼叫急救中心/医生。
Production methods and uses
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upstream information
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downstream information
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MSDS
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