compound introduction
GNF-7 抑制 Bcr-Abl WT 和 Bcr-Abl T315I, IC50 分别为133 nM 和 61 nM。 GNF-7 is a potent type-II kinase Bcr-Abl inhibitor with IC50 of
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GNF-7
Dangerous GoodsCAS number：839706-07-9 molecular formula：C28H24F3N7O2
overview
Specs
| Chinese alias | N-(4-Methyl-3-(1-methyl-7-(6-methylpyridin-3-ylamino)-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)phenyl)-3-(trifluoromethyl)benzamide; N-[3-[1,4-Dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylpheny | ||
| English alias | N-(4-Methyl-3-(1-methyl-7-(6-methylpyridin-3-ylamino)-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)phenyl)-3-(trifluoromethyl)benzamide; N-[3-[1,4-Dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylpheny | ||
| CAS number | 839706-07-9 | molecular formula | C28H24F3N7O2 |
| molecular weight | 547.542 g/mol | Exact mass | 10mM in DMSO |
| PSA | 103.000 Ų | logp | 4.300 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS06
Signal word：
Danger
Hazard Statement：
H301: 吞咽会中毒
Statement of Preventive Measures：
P301+P310: 如误吞咽：立即呼叫急救中心/医生。
Production methods and uses
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upstream information
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downstream information
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MSDS
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