compound introduction
Decernotinib (VX-509)是一种有效的且选择性的JAK3抑制剂，Ki 为 2.5 nM，分别比作用于JAK1，JAK2，和 TYK2的选择性高4倍以上。Phase 2/3。 Decernotinib 是一种有效的，可口服的 JAK3 抑制剂，对 JAK3，JAK1，JAK2 和 TYK2 的 Ki 值分别为 2.5，11，13 和 11 nM。
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Decernotinib (VX-509)
Dangerous GoodsCAS number：944842-54-0 molecular formula：C18H19F3N6O
overview
Specs
| Chinese alias | 地塞诺替尼(VX-509) | ||
| English alias | Butanamide, 2-methyl-2-((2-(1H-pyrrolo(2,3-b)pyridin-3-yl)-4-pyrimidinyl)amino)-N-(2,2,2-trifluoroethyl)-, (2R)- | F18308 | NCGC00402345-03 | VX 509 | Decernotinib(VX-509) | Decernotinib (VX-509,adelatinib) | Decernotinib [USAN:INN] | MZK2GP0RHK | (2R)-2- | ||
| CAS number | 944842-54-0 | molecular formula | C18H19F3N6O |
| molecular weight | 392.38 g/mol | Exact mass | - |
| PSA | 95.600 Ų | logp | 3.1 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
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