Dimethindene maleate is a selective histamine H1 antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions In Vitro Dimethindene maleate (1-1000 μM) suppresses the cromakalim-induced/glibenclamide-sensitive K ＋ currents in a concentration-dependent and reversible manner with an IC 50 value of 29.5 μM. Dimethindene maleate (1-1000 μM) inhibits Y-26763-induced glibenclamide-sensitive K ＋ currents with an IC 50 value of 49 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Dimethindene maleate (0.25 mg; i.p. once) affects wound healing in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 mice with wound healing Dosage: 0.25 mg Administration: Intraperitoneal injection; 0.25 mg once Result: Significantly delayed skin wound and only showed wound closure impairment in the initial phase wound healing. Form:Solid IC50& Target:IC50: 29.5 μM (cromakalim-induced K ＋ currents), 49 μM (Y-26763-induced K ＋ currents)
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Dimethindene maleate
Dangerous GoodsCAS number：3614-69-5 molecular formula：C24H28N2O4
overview
compound introduction
Specs
| Chinese alias | 马来酸二甲基茚啶 | ||
| English alias | D01343 | WS-01911 | Dimetindene hydrogen maleate | Fenistil-retard | Dimethindene maleate (USAN) | NSC107677 | NSC-107677 | Triten | Dimetindene maleate (JAN) | DIMETINDENE MALEATE [EP MONOGRAPH] | Dimethindenmaleat | But-2-enedioic acid;N,N-dimethyl-2-[3 | ||
| CAS number | 3614-69-5 | molecular formula | C24H28N2O4 |
| molecular weight | 408.49 g/mol | Exact mass | - |
| PSA | 90.700 Ų | logp | - |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS09 , GHS07
Signal word：
Warning
Hazard Statement：
H411: 对水生生物有毒并具有长期持续影响 H302: 吞食有害
Statement of Preventive Measures：
P273: 避免释放到环境中。 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P391: 收集溢出物 P330: 漱口 P301+P317: 如果被吞咽：请寻求医疗帮助。
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