Stauprimide is an indolocarbazole semi-synthetic small molecule shown to significantly increase the efficiency of directed embryonic stem cell differentiation. Stauprimide inhibits the nuclear localization of NME2, blocking and downregulating c-Myc expression. The expression of c-Myc is crucial for embryonic stem cell self-renewal, and intervention by Stauprimide allows for more efficient lineage-specific differentiation. NME2 is also indicated to be upregulated in certain cancers, indicating further application for the blocking action of StauprimideAn indolocarbazole promoter of embryonic stem cell differentiation. Stauprimide is an indolocarbazole semi-synthetic small molecule shown to significantly increase the efficiency of directed embryonic stem cell differentiation. Stauprimide inhibits the nuclear localization of NME2, blocking and downregulating c-Myc expression. The expression of c-Myc is crucial for embryonic stem cell self-renewal, and intervention by Stauprimide allows for more efficient lineage-specific differentiation. NME2 is also indicated to be upregulated in certain cancers, indicating further application for the blocking action of Stauprimide An indolocarbazole promoter of embryonic stem cell differentiation.
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
Stauprimide
Dangerous GoodsCAS number：154589-96-5 molecular formula：C35H28N4O5
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | Q7604751 | [9S-(9alpha,10beta,11beta,13alpha)]-N-(2,3,10,11,12,1 3-Hexahydro-10-methoxy-9-methyl-1,3-dioxo-9,13-epo xy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j] [1,7]benzodiazonin-11-yl)-N-methylbenzamide | HY-N6747 | N-((9S,10R,11R,13R)-2,3,10,1 | ||
| CAS number | 154589-96-5 | molecular formula | C35H28N4O5 |
| molecular weight | 584.62 g/mol | Exact mass | ≥99% |
| PSA | 94.800 Ų | logp | 4.800 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
WGK Germany：
3
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
