compound introduction
C646 是一种histone acetyltransferase抑制剂，抑制p300，无细胞试验中Ki为400 nM，相比于其它乙酰转移酶，优先作用于p300。C646 可诱导细胞周期阻滞、细胞凋亡与自噬。 C646 was used to study the role of p300 in chronic neuropathic pain in rats with chronic constriction injury.
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C 646
Dangerous GoodsCAS number：328968-36-1 molecular formula：C24H19N3O6
overview
Specs
| Chinese alias | 4-[4-[[5-(4,5-二甲基-2-硝基苯基)-2-呋喃基]亚甲基]-4,5-二氢-3-甲基-5-氧代-1H-吡唑-1-基]苯甲酸 | 4-[4-[[5-(4,5-二甲基-2-硝基苯基)-2-呋喃基] 亚甲基]-4,5-二氢-3-甲基-5-氧代-1H-吡唑-1-基] 苯甲酸 | ||
| English alias | 4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid | CHEBI:132974 | Q27075626 | BRD-K73383190-001-03-1 | GTPL7004 | 4-(4-{[5-(4,5-dimethyl-2-nitrophenyl)-2-furyl]methylene}-3-methyl-5-oxo-4,5 | ||
| CAS number | 328968-36-1 | molecular formula | C24H19N3O6 |
| molecular weight | 445.42 g/mol | Exact mass | - |
| PSA | 129.000 Ų | logp | 4.200 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS09
Signal word：
Warning
Hazard Statement：
H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响
Statement of Preventive Measures：
P273: 避免释放到环境中。 P501: 将内容物/容器处理到。。。 P391: 收集溢出物
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MSDS
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