PF-2341066 shows inhibition of Met phosphorylation in mIMCD3 mouse of MDCK canine epithelial cells with an IC50 of 5 nM and 20 nM, respectively, as well as NCI-H69 and HOP92 cells, with an IC50 of 13 nM and 16 nM, respectively. PF-2341066 shows a near-equivalent IC50 of 24 nM against the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) oncogenic fusion varient of the ALK RTK expressed by the KARPAS299 human anaplastic large-cell lymphoma (ALCL) cell line. PF-2341066 supresses human GTL-16 gastric carcinoma cell growth with an IC50 of 9.7 nM. PF-2341066 induces apoptosis in GTL-16 cells with an IC5050 of 30 nM. A Met inhibitor effective against various cell lines Crizotinib has been used: · to investigate its effects on hepatocyte growth factor receptor (c-Met) expression, proliferation and apoptosis · to block neurotrophic tyrosine kinase receptor type 1 (NTRK1) activity in epithelial cells · to restore sensitivity to erlotinib PF-2341066 shows inhibition of Met phosphorylation in mIMCD3 mouse of MDCK canine epithelial cells with an IC50 of 5 nM and 20 nM, respectively, as well as NCI-H69 and HOP92 cells, with an IC50 of 13 nM and 16 nM, respectively. PF-2341066 shows a near-equivalent IC50 of 24 nM against the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) oncogenic fusion varient of the ALK RTK expressed by the KARPAS299 human anaplastic large-cell lymphoma (ALCL) cell line. PF-2341066 supresses human GTL-16 gastric carcinoma cell growth with an IC50 of 9.7 nM. PF-2341066 induces apoptosis in GTL-16 cells with an IC5050 of 30 nM. A Met inhibitor effective against various cell lines Crizotinib has been used: · to investigate its effects on hepatocyte growth factor receptor (c-Met) expression, proliferation and apoptosis · to block neurotrophic tyrosine kinase receptor type 1 (NTRK1) activity in epithelial cells · to restore sensitivity to erlotinib
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Crizotinib
Dangerous GoodsCAS number：877399-52-5 molecular formula：C21H22Cl2FN5O
overview
compound introduction
Specs
| Chinese alias | 克里唑替尼 | 3-[(1R)-1-(2,6-二氯-3-氟苯基)乙氧基]-5-[1-(4-哌啶)-1H-吡唑-4-基]-2-吡啶胺 | 克唑替尼 | (R)-3-[1-(2,6-二氯-3-氟 - 苯基)-乙氧基]-5-(1-哌啶-4-基-1H-吡唑-4-基)-吡啶-2-基胺 | ||
| English alias | PF02341066 | PF 2341066 | 1-[(2R,5R)-5-ethynyl-5-(hydroxymethyl)-2H-furan-2-yl]-5-methyl-pyrimidine-2,4-dione | NCGC00250400-09 | BB 0261738 | CRIZOTINIB [MART.] | VGH | CHEBI:64310 | DTXSID40193304 | PF 2341066 | KBio2_002584 | 3-((1R)-1-(2,6-DICHLORO-3- | ||
| CAS number | 877399-52-5 | molecular formula | C21H22Cl2FN5O |
| molecular weight | 450.34 g/mol | Exact mass | ≥99% |
| PSA | 78.000 Ų | logp | 3.7 |
numbering system
No numbering system information yet
physicochemical properties
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Safety information
pictogram：
GHS08 , GHS09 , GHS07
Signal word：
Warning
Hazard Statement：
H319: 引起严重眼睛刺激 H341: 怀疑引起遗传缺陷 H318: 造成严重的眼睛损伤 H317: 可能引起皮肤过敏反应 H400: 对水生生物有剧毒
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P281: 根据需要使用个人防护设备。 P272: 被污染的工作服不允许离开工作场所
UN Number：
3077
Packing Group：
III
Production methods and uses
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Related
upstream information
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downstream information
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MSDS
Found 0 shareMSDS
