Information PX-478 2HCl PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. PX-478 2HCl induces apoptosis and has anti-tumor activity. Phase 1. Targets HIF-1α In vitro PX-478 lowers HIF-1α protein levels and HIF-1 transactivation in hypoxia and in normoxia in a variety of cancer cell lines, but has a more pronounced effect on translation of proteins, such as HIF-1α in hypoxia. PX-478 also enhances the radiosensitivity of prostate carcinoma PC3 cells. In vivo In HT-29 human colon cancer xenografts, PX-478 suppresses HIF-1alpha levels and inhibits the expression of HIF-1 target genes including vascular endothelial growth factor and the glucose transporter-1. In addition, PX-478 (100 or 120 mg/kg i.p.) also shows antitumor activity including cures against several established human tumor xenografts that is related to the levels of HIF-1α. In high-fat-diet mice, PX-478 causes reduced fibrosis and fewer inflammatory infiltrates in their adipose tissues.
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PX-478 2HCl
Dangerous GoodsCAS number：685898-44-6 molecular formula：C13H20Cl4N2O3
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | A867013 | PX 478 [WHO-DD] | Q27289565 | s7612 | CCG-268582 | PX 478 | AKOS030231369 | AS-76128 | DTXSID00218688 | SCHEMBL18548830 | AC2217 | BDBM50231387 | L-Phenylalanine, 4-(bis(2-chloroethyl)oxidoamino)-, dihydrochloride | A14319 | PX478 | PX-478 | HY- | ||
| CAS number | 685898-44-6 | molecular formula | C13H20Cl4N2O3 |
| molecular weight | 394.12 g/mol | Exact mass | - |
| PSA | 81.400 Ų | logp | -0.251 |
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physicochemical properties
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Safety information
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
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