SBI-0206965

Dangerous Goods

CAS number：1884220-36-3 molecular formula：C21H21BrN4O5

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

SBI-0206965 是一种高度选择性自吞噬激酶ULK1抑制剂，IC50为108 nM，选择性比作用于ULK2高7倍。SBI-0206965 可抑制人胶质母细胞瘤和肺癌细胞中的自噬而增强凋亡。 Information SBI-0206965 SBI-0206965 is a highly selective autophagy kinase ULK1 inhibitor with IC50 of 108 nM, about 7-fold selectivity over ULK2. SBI-0206965 inhibits autophagy and enhances apoptosis in human glioblastoma and lung cancer cells. Targets ULK1 (Cell-free assay); ULK2 (Cell-free assay) 108 nM; 711 nM In vitro In HEK293T transfected with WT or KI Myc-tagged ULK1 and WT Vps34, SBI-0206965 inhibits Ser249 phosphorylation of overexpressed Vps34 and Beclin1 Ser15 phosphorylation. SBI-0206965 suppresses autophagy induced by mTOR inhibition in A549 cells, and prevents ULK1-dependent cell survival in WT MEFs. In addition, SBI-0206965 also synergizes with mTOR inhibition to induce cancer cell death.

Specs

Chinese alias	-
English alias	SBI-0206965 \| 1884220-36-3 \| Sbi0206965 \| 2-((5-Bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide \| 2-[5-bromo-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]oxy-N-methylbenzamide \| 2-({5-bromo-2-[(3,4,5-trimethoxyphenyl)amino]pyrimi
CAS number	1884220-36-3	molecular formula	C21H21BrN4O5
molecular weight	489.32 g/mol	Exact mass	-
PSA	104.000 Å²	logp	4.128

numbering system

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physicochemical properties

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Safety information

pictogram：

GHS07

Signal word：

Warning

Hazard Statement：

H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激

Statement of Preventive Measures：

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移