HA15 是一种特异靶向 HSPA5 (Heat shock 70kDa protein 5) 也可称为 BiP (Immunoglobulin heavy-chain-binding protein) 或 Grp78 (glucose-regulated protein 78) 的小分子。在所检测的黑色素瘤细胞中具有抗肿瘤活性，包括从病人中分离得到的细胞和对BRAF抑制剂具有耐药性的细胞。 Information HA15 HA15 is a molecule that targets specifically HSPA5 (Heat shock 70kDa protein 5) also known as BiP (Immunoglobulin heavy-chain-binding protein) or Grp78 (glucose-regulated protein 78) . HA15 displays anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors. Targets BiP/GRP78/HSPA5 In vitro HA15 induces ER stress leading to cancer cell death in vitro and overcomes BRAF inhibitor resistance in melanoma cells. In vivo HA15 induces ER stress leading to cancer cell death and exhibits strong efficacy in xenograft mouse models with melanoma cells either sensitive or resistant to BRAF inhibitors.
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HA15
Dangerous GoodsCAS number：1609402-14-3 molecular formula：C23H22N4O3S2
overview
compound introduction
Specs
| Chinese alias | N- [4- [3-[[[5-(二甲基氨基)-1-萘基]磺酰基]氨基]苯基] -2-噻唑基]-乙酰胺 | ||
| English alias | - | ||
| CAS number | 1609402-14-3 | molecular formula | C23H22N4O3S2 |
| molecular weight | 466.58 g/mol | Exact mass | 10mM in DMSO |
| PSA | 128.000 Ų | logp | 4.000 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
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MSDS
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