Evacetrapib (LY2484595)是高活性CETP选择性抑制剂,IC50为5.5 nM,能在不增加醛固酮和血压的情况下提高高密度脂蛋白胆固醇。 Evacetrapib (LY2484595) is a potent and selective inhibitor of CETP with IC50 of 5.5 nM, elevates HDL cholesterol without increases in aldosterone or blood pressure.
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Evacetrapib (LY2484595)
Dangerous GoodsCAS number:1186486-62-3 molecular formula:C31H36F6N6O2
overview
compound introduction
Specs
| Chinese alias | 依瓦塞特拉匹布 (LY2484595) | ||
| English alias | Trans-4-(((5S)-5-(((3,5-bis(trifluoromethyl)phenyl)methyl)(2-methyl-2H-tetrazol-5- yl)amino)-7,9-dimethyl-2,3,4,5-tetrahydro-1H-benzazepin-1-yl)methyl) cyclohexanecarboxylic acid | Q553129 | 2-pyridine-carboxaldehyde | 4-trans-(((S)-5-((3,5-Bis(trifluorom | ||
| CAS number | 1186486-62-3 | molecular formula | C31H36F6N6O2 |
| molecular weight | 638.65 g/mol | Exact mass | - |
| PSA | 87.400 Ų | logp | 7.7 |
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physicochemical properties
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Safety information
pictogram:
GHS08 , GHS09
Signal word:
Warning
Hazard Statement:
H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响 H361: 怀疑破坏生育力或未出生的孩子
Statement of Preventive Measures:
P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P391: 收集溢出物 P203: 使用前,获取、阅读并遵守所有安全说明。 P318: 如果暴露或担心,请就医。
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